Seahawks (5-0) at Cardinals (4-2)
Sunday, 4:05 p.m. ET, State Farm Stadium, Glendale, Ariz. TV: Fox
Danny Sheridan’s line: Seahawks by 3
Seahawks’ keys to victory: Continue doing what they’ve been doing. QB Russell Wilson has 19 TD passes against three interceptions. The Cardinals have one interception but have been surprisingly solid against the pass, entering Week 6 with the league’s No. 4 passing defense. However, their defense must do better than the 471 yards they are allowing per game against an Arizona team that has a number of offensive weapons.
Cardinals’ keys to victory: Generate pressure without OLB Chandler Jones to keep Wilson from doing too much damage. The Cardinals will need to continue to be great defensively on third down and in the red zone. Entering Week 6, they ranked fourth in third-down defense and second in red-zone defense. QB Kyler Murray will need to lead TD drives against the league’s worst defense in terms of yards and not turn the ball over.
Matchup to watch: Cardinals WR DeAndre Hopkins vs. Seahawks CB Quinton Dunbar. Hopkins has had three games this season with at least 130 yards and was the NFL’s leader in both receptions and receiving yards entering Week 6. Seattle already gives up the most passing yards in the league and more than 370 yards per game, so limiting arguably the league’s best wide receiver will be a huge challenge.
Who wins? It will be another high-scoring affair, but the Arizona defense will keep Wilson from another fourth-quarter comeback. Murray will have a big game in the air and on the ground.
Cardinals, 34-31